Correct answer: Chronic Spontaneous Urticaria (CSU)
Learn more about the guideline-based diagnosis of chronic spontaneous urticaria with this interactive patient case.
Learn moreThis case is a classic example of chronic spontaneous urticaria. Features that support this diagnosis:
- Wheals that arise spontaneously
- Wheals that are itchy
- Individual wheals that resolve within 24 hours and without bruising
- Wheals that recur for more than 6 weeks
- Absence of fever, malaise, joint pain and bone pain
Chronic spontaneous urticaria (CSU) is characterized by the presence of hives, angioedema, or both, recurring for more than 6 weeks in the absence of an identifiable trigger (Zuberbier et al, 2022). CSU is the most common subtype of chronic urticaria (CU) and occurs more commonly in adults than children.1 More than half of patients with CSU are not in remission at 5 years.2 Up to 90% CSU patients have a history of wheals (hives), while up to 40% CSU patients have a history of angioedema (deeper swelling) that typically involves the peri-oral and peri-orbital areas and extremities. Wheals and angioedema may be misdiagnosed as an allergic reaction or even anaphylaxis, which can lead to diagnosis and treatment delays. However, CSU is a chronic inflammatory disease (not an allergic reaction), patients do not present with signs of anaphylaxis (dizziness, dyspnea, nausea, diarrhea), and CSU does not involve the larynx (Kaplan and Ferrer, 2024).
The incorrect answers are:
- Atopic dermatitis presents with pruritic, erythematous or lichenified patches with indistinct margins, typically in the flexural areas. Lesions are persistent and may be excoriated by scratching.
- Chronic inducible urticaria is a condition that also last more than six weeks and includes wheals that come and go in less than 24 hours. However, chronic inducible urticaria has identifiable causes including cold, heat, sun, pressure, vibration, contact, exercise, and water.
- Acute urticaria is defined as the occurrence of wheals, angioedema, or both for 6 weeks or less. A cause of acute urticaria may be identified (viral infection, food/drug allergy).
- Urticarial vasculitis lesions are longer-lasting and are often painful or ‘burning’ and they may leave residual bruising or hyperpigmentation of the skin. A biopsy is required to make the diagnosis with histologic certainty. The wheals clinically resemble urticaria, but histology shows leukocytoclastic vasculitis.
- An allergic reaction can present with wheals and angioedema, although typically with recent onset combined with a history of known allergies or new medications, new foods, or new skin products.